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The Mysterious Conductor of the Hair Cycle Clock

The Mysterious Conductor of the Hair Cycle Clock

One of the oldest explanations for baldness in the Western world was the "exhaustion of nervous energy"—that is, the health and capability of the nervous system. In the 1881 book, American Nervousness, George W. Beard explains that baldness and many other problems increase at the expense of nervous energy due to the stress and strain of modern life.

Antihistamines for Pattern Hair Loss?

Antihistamines for Pattern Hair Loss?

Over the years, a few people have been interested in the ability of antihistamine drugs to completely reverse baldness. For instance, in a small group of ten women with so-called androgenic alopecia an antihistamine called cimetidine showed good to excellent regrowth of hair in seven out of the ten women.[1] In addition to hair regrowth, acne, seborrhea, and hirsutism, which were present in three of the patients, showed significant improvement. Most of the women said that their scalps had become less greasy taking the drug similar to Hamilton's famous immune-to-baldness castrates. 

Recharging The Mosaic Cycle: The Role of G6PDH in Baldness

Recharging The Mosaic Cycle: The Role of G6PDH in Baldness

One of my favorite films of 2014 was The Internet’s Own Boy, a film that chronicled the life and death of boy genius and anti-authoritarian activist, Aaron Swartz. Almost immediately after the film was over (you can watch it here on YouTube), I remember reaching out to my friend Karen to tell her how much I enjoyed the film. Half way into our conversation we both noted that Aaron had a great head of hair, and Karen went on to say that she noticed that Aaron’s hair seemed to dim during the times of the film that the documentary discussed Aaron’s digestive ailment, Crohn’s disease. 

The Baldness Field, Part II: In Search of a Unifying Theory of Pattern Hair Loss

The Baldness Field, Part II: In Search of a Unifying Theory of Pattern Hair Loss

Recently, I've been writing about a possible explanation for the "horseshoe" shape of pattern baldness, as well as a more specific pathology for the loss hair. I tackled these subjects a little bit in The Baldness Field but ironically didn’t go over them at all in the book, Hair Like a Fox. I think this was because, 1) I didn’t know and, 2) I didn’t have the same access to research that I do now. Access to research is actually one of the biggest steps forward I’ve ever encountered, and being able to peruse the history of baldness—while others cannot—is a certifiable tragedy.

Coming to Terms with My Life as a Walking Aquarium

Coming to Terms with My Life as a Walking Aquarium

To understand the current state of the alternative health universe, you have to understand where Kurt Harris fits in. Kurt was one of the first intelligent people I came across in my health journey, and at the time, similar to Matt Stone, had a large effect on me. While some people think his synthesis propelled him into the territory of a Masterjohn or a Guyenet, I think his rise to stardom was mostly due to his humor.

The Centrality of The Liver in Pattern Baldness: Estrogen, Aspirin, and IGF-1

The Centrality of The Liver in Pattern Baldness: Estrogen, Aspirin, and IGF-1

After consuming only meat and water everyday for two years, there came a point where I felt like I was constantly on edge. This feeling was not only evident to me, but anyone who was around me on a regular basis, especially my former band mates. For instance, the singer of Takota, who I was closest to, told me that 99% of the time he was around he felt like he was walking on eggshells. This eggshell walking was most evident on tour, where I was a complete raging lunatic — regularly throwing temper tantrums in protest of the guitar player's actions who I had a love/hate relationship with. In retrospect, this orientation is almost expected given my my no-carb diet, which induced a state of near constant low blood sugar.

The Character Armor of Pattern Baldness: Anxiety, Depression, and Learned Helplessness

The Character Armor of Pattern Baldness: Anxiety, Depression, and Learned Helplessness

In 1950 Szasz et al. noticed something that anyone who has ever visited a baldness forum is well aware of: Men experiencing pattern baldness tend to have defensive attitudes.[1] While one only needs to venture to the Hair Loss Help forum thread entitled, "If you're bald you don't need to kill yourself, you're already dead" to view an example of the despair and hopelessness in the balding community,[2] Szasz et al. came to their conclusion after observing that "toothy smiles" and ridged facial expressions were common among balding males.

Iron Overload, Perturbed Redox Balance, and Meddling Serotonin

Iron Overload, Perturbed Redox Balance, and Meddling Serotonin

Iron is a very basic anti-respiratory factor, inhibiting the last crucial step of oxidative mitochondrial metabolism, cytochrome c oxidase.[1] Iron tends to accumulate with age in both sexes,[2] but to a lesser degree in women due to the menstrual cycle. However, this "iron advantage"—which may help explain the increased longevity of females—is lost at menopause.

Omega-3 Fatty Acids: Hair Loss Wunderkind or Arbiter of Doom?

Omega-3 Fatty Acids: Hair Loss Wunderkind or Arbiter of Doom?

Citizen hair loss scientists are certain about a few things:

  • DHT, or rather the genetically determined androgen receptor, is the cause of baldness.
  • Finasteride, minoxidil, and nizoral ("the big 3") are the only effective treatments for pattern hair loss.
  • And most importantly, based on a series of deductions that have nothing to do with current body of evidence surrounding hair loss, they have determined that diet and lifestyle have nothing to do with the genesis of so-called male-pattern baldness.

Unravelling The Mystery of Baldness With Cyproterone Acetate

Unravelling The Mystery of Baldness With Cyproterone Acetate

In the 2013 release of, HAIR LIKE A FOX, I hypothesized that castrated males were resistant to baldness because they had higher levels of progesterone, and lower levels of estrogen and prolactin, which cause metabolic stress. Progesterone not only supports mitochondrial energy metabolism (which appears to go off the rails in pattern hair loss), but also efficient blood circulation in the scalp, which is impaired in baldness. 

The Indescribable, Indefinite, Undefined Gene

The Indescribable, Indefinite, Undefined Gene

The idea that genes are running the show, or "genetic determinism" courses through the veins of medical and diet culture. It has been slightly modified over the years with the emerging field of "epigenetics" (i.e., genes are "turned on or off" by environmental factors), but the message is still clear: We must conquer our inherited blueprints—"the genes"—if we wish to be problem free.

Psychosis or Gnosis: A Social History of LSD

Psychosis or Gnosis: A Social History of LSD

A couple of weekends ago, I was able to witness a few friends drop acid and wander through the vineyards of Napa Valley. This was entertaining for two reasons, 1) many of my friends are ballet dancers and upon taking the drug began an assault on the senses with aerial acrobatics, and 2) lysergic acid diethylamide (LSD) is a serotonin antagonist (Martin, 1985; Gaddum and Hameed, 1954; Savini, 1956), suggesting that their actions during that time were ostensibly related to their drowned out serotonin levels.