Generative Energy #11: Nitric Oxide and Methylene Blue


Listen to Georgi and I discuss a bioenergetic view of nitric oxide and methylene blue in the real organism on episode #11 of The Generative Energy Podcast! 

“The true method of knowledge is experiment.” —William Blake

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01:16 - “Without self knowledge, without understanding the working and functions of his machine, man cannot be free, he cannot govern himself and he will always remain a slave.” —G.I. Gurdjieff
03:05 - Can good health be sustained by someone telling you what to do?
04:00 - “The attempt to steer a person can make it hard for them to move, because it inactivates their own guidance system.” —How do you know? Students, patients, and discovery by Raymond Peat, PhD
05:00 - Ray Peat’s Nitric Oxide Interviews (link:
05:45 - Mainstream views of nitric oxide
06:25 - Can be thought of as an emergency substitute for carbon dioxide to dilate blood vessels (CO2)
07:14 - Nitric oxide can influence intracellular calcium levels
07:51 - Local vs. systemic release of nitric oxide
08:50 - Nitric oxide and lactate stimulate angiogenesis
09:20 - Nitric oxide irreversibly binds cytochrome c oxidase
10:28 - Infections acutely increase nitric oxide
11:05 - Good thyroid function for low levels of nitric oxide
11:30 - Caffeine, niacinamide, zinc, and magnesium can help lower nitric oxide
12:00 - The amino acid lysine can lower nitric oxide
12:27 - Health problems associated with nitric oxide (and testing it)
13:23 - Nitric oxide theory of aging (2012)
14:19 - Chronic disease is associated with elevated levels of nitric oxide and contributes to the problem
15:39 - Activating cytochrome c oxidase to lower nitric oxide
16:10 - Red light and methylene blue lower nitric oxide
16:55 - Nitric oxide can lower the core temperature
17:33 - Methylene blue can act as a substitute for oxygen in cellular respiration
18:40 - Lactate dehydrogenase (LDH) is overexpressed in cancer
19:19 - Testing lactate dehydrogenase (LDH)
20:30 - Good nutrition, thyroid, progesterone, methylene blue, and aspirin all inhibit nitric oxide
21:05 - Vitamin A and vitamin D for thyroid health
21:20 - Bad bacteria can prevent a normal temperature
22:50 - Vitamin A deficiency - what are the signs?
23:32 - Vitamin A and progesterone are similar
24:09 - Vitamin A is an anti-estrogen
25:05 - Vitamin A for sleep (anecdote)
25:27 - Are higher doses of vitamin A dangerous?
27:45 - Vitamin A and progesterone confusion
29:09 - Doses of methylene blue in experiments
30:16 - Methylene blue and red light together
31:28 - Can you use methylene blue topically?
32:23 - Taurine is more effective than finasteride study
33:26 - Methylene blue redox test
34:34 - Tetracyclines for lowering nitric oxide
36:00 - Caffeine reduces exhaled nitric oxide
36:26 - Side-effects of Viagra
37:05 - Viagra may be carcinogenic
37:21 - Assessing nitric oxide status
38:55 - Is the blood level of carbon dioxide (CO2) accurate?
40:58 - Breathing through your nose as a metric for CO2
42:10 - Where can we find more of your work, Georgi?
44:19 – Ray Peat email exchanges (link: