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"A conclusion has been made that one of the most important mechanisms of the adaptive effect of prolactin is its ability to suppress thyroid function, thus decreasing the metabolism level, which results in reduction of oxygen consumption…"
"Subsequent actions of prolactin may involve the following: a) an increased intracellular concentration of potassium and a reduced level of sodium, b) an increased level of cGMP and a reduced level of cAMP, c) an enhanced rate of prostaglandin biosynthesis mediated by a stimulation of phospholipase A2 activity, and d) a stimulation of polyamine synthesis."
"...serum prolactin concentrations reflect endogenous serotonin..." "...aromatase activity correlated significantly with prolactin..."
"After glucose load the hyperprolactinaemic patients showed a decrease in glucose tolerance and a hyperinsulinaemia." "These findings suggest a diabetogenic effect of prolactin."
"These observations indicate that cutaneous symptoms such as seborrhea, acne, hypertrichosis/hirsutism, alopecia may evidently occur in hyperprolactinemia, representing or mimicking androgen-induced skin symptoms. In such cases, therefore, evaluation of prolactin levels together with androgen blood levels and thyroid gland function tests should be performed to exclude underlying endocrinopathy."
1. Metabolism of thyroid gland cells as affected by prolactin and emotional-physical stress (1991)
2. Mechanism of prolactin action (1980)
3. Effects of aromatase inhibition and androgen activity on serotonin and behavior in male macaques (2013)
4. Prolactin: a diabetogenic hormone (1977)
5. Disorder of hair growth in hyperprolactinemia (1988)