Generative Energy #15: A Bioenergetic View of Addiction

 
 

Listen to Georgi and me discuss a bioenergetic view of addiction on episode #15 of The Generative Energy Podcast! 

“The true method of knowledge is experiment.” —William Blake

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01:15 - Some of Danny’s thoughts on addiction
02:47 - Addiction is viewed as genetic predisposition (ΔFosB)
03:39 - Environmental factors (CREB and NF-κB)
04:08 - Reframing addiction as high inflammation
05:38 - ‘Addiction is a moral deficit’ anecdote
06:35 - Addiction in other organisms (self-medication)
07:24 - ‘Therapies for addiction don’t work’
08:12 - ‘Growing out of an addiction’
09:57 - ’98% chance of relapse’
10:10 - Is “diagnosis” part of the problem?
10:33 - Learned helplessness and so-called addiction
11:07 - Rat Park (http://bit.ly/1OS3sY1)
12:18 - ‘Organisms will do almost anything to relieve stress’
13:34 - Learned helplessness, dopamine, and serotonin
14:51 - Alcohol and estrogen (http://1.usa.gov/1jP5DyK)
16:01 - ‘Estrogen damages negative feedback of cortisol system’
16:50 - Prolactin is a good biomarker for stress
17:35 - The mystique of drugs in our culture (http://on.fb.me/1jP80BJ)
19:27 - Is marijuana a good adaptogen?
20:12 - ‘Marijuana shouldn’t be smoked’
21:04 - ‘Positive effects of marijuana might be due to increasing pregnenolone’
22:00 - ‘Safer alternatives to marijuana…’
22:34 - Living in a state of learned helplessness
23:38 - Escaping learned helplessness (or retaining “agency”)
24:46 - The metabolism and “perceive, think, act”
26:12 - The first two casualties of metabolic stress
27:20 - ‘Increasing GABA decreases metabolic stress’
28:08 - NF-κB and  TNF-a—mediators of inflammation and stress
30:19 - Is it “natural” to take thyroid hormone?
32:00 - Broda Barnes, alcoholism, and low thyroid
32:59 - ‘One of the major reasons to take thyroid hormone’
34:17 - ‘An environment that promotes metabolic stress’ (sorry for the background noise in this section)
35:39 - Temperature, pulse, and useful labs for addiction
38:34 - Danny is skeptical of lab tests, but gets them anyway
39:43 - “The number of calories burned is a good indicator of the metabolic rate. The amount of water lost by evaporation is another rough indicator: For each liter of water evaporated, about 1000 calories are burned.“ —RP (http://bit.ly/1jPgCIn)
40:32 - Pharmacological options for addiction (cyproheptadine and clonidine) 
42:10 - ‘If opposing stress cures addiction…’
43:43 - Georgi, where can we find more of your work on the Internet this week