Aspirin: The "Swiss Army Knife" of Baldness Remedies?

00:00 - Introduction

01:47 - Brain Atrophy in Androgenic Alopecia? (My New Theory) https://youtu.be/956IF0oDfZY

02:12 - Ata Korkmaz HA. Relationship between androgenic alopecia and white matter hyperintensities in apparently healthy subjects. Brain Imaging Behav. 2019 Jun 27. https://www.ncbi.nlm.nih.gov/pubmed/31250269

03:30 - "Estrogen, hyperventilation, lactate, etc., increase serotonin, and I think it’s serotonin that directly increases PTH, and then PTH increases NO.” Raymond Peat, Ph.D. (2017)

03:59 - The relationship between insulin resistance, arterial stiffness, hypertension, baldness, and white matter hyperintensities

06:26 - "Surgeons will say many things to get customers, but one website promoting removal of enlarged parathyroid glands makes the interesting comment that they see an average of three women per day who are going bald from hyperparathyroidism. 'The longer they have hyperparathyroidism the more hair they lose.'" Adaptogenic Milk by Raymond Peat, Ph.D. (2017)

06:57 - Aspirin might help reverse white matter hyperintensities, and opposes, estrogen, hyperventilation, lactic acid, serotonin, parathyroid hormone, cortisol, aldosterone, and nitric oxide.

08:46 - "The highest activity a human being can attain is learning for understanding, because to understand is to be free." Spinoza

09:52 - Aspirin caveats: vitamin K, dissolving the aspirin with baking soda, and using alongside a meal.

6 Things I Wish I Knew About Ray Peat Inspired Nutrition

00:00 - Introduction: How I Got to Ray Peat

01:07 - Part I: Collect Self-Metrics & Find The Best Information Available

02:53 - Part II: Antibiotic Foods, Sporebiotics & Safe Pharma Antibiotics

05:31 - Part III: Source Sweet Juicy Fruits & Avoid Tart, Sour & Unripe Rruits

07:34 - Part IV: Adopting a Judicious Attitude Towards Supplements

09:12 - Part V: The Irreplaceable Value of Ruminant Liver & Oysters

10:51 - Part VI: Learning to Cook is a Necessary Skill

What is Health? Comparing Zero-Carb, Vegan & Bioenergetic Models

00:00 - Introduction

00:46 - Part I: The Starting Orientation for Vegans, Carnivores & Bioenergetic Advocates

05:17 - Part II: Raymond Pearl's Rate of Living Theory, Carbs, NEFA, Fasting & Cold Exposure

08:18 - Part III: Hans Selye's Stress in Context

08:58 - Part IV: PUFA - A Ubiquitous Environmental Stressor That Is Stored In Your Tissues

10:53 - Part V: Carbon Dioxide - An "Essential Vitamin"

12:41 - Part VI: Thoughts on "Health" & Resisting The Rigidity of Aging

Why I Quit The Zero-Carb Carnivore Diet After 2-Years

00:00 - My History with Zero-Carb

01:50 - Negative Symptoms I Experienced (e.g., Mood, Libido, Outlook, etc.)

02:30 - My Experience with The Zero-Carb Community

04:08 - Why I Suspect My Health Initially Improved

05:25 - Why I Suspect Zero-Carb Causes Hypometabolism (i.e., Metabolic Stress)

06:30 - Stress Can Cause Short-Term Euphoria

07:58 - Cholesterol as a Mirror Image of Thyroid Function

09:35 - Phosphorous, Calcium & PTH

Generative Energy #31: Safe Supplements with Raymond Peat, PhD

 
 

01:10 - Ray Peat on Culture, Government, and Social Class (http://bit.ly/2hC7qdd) Why Kerala, Grampa? (http://bit.ly/2hQOpBK)
06:16 - Danny’s evolving views on supplements
07:00 - “When your intestine is extremely sensitive, the excipients and contaminants in a pregnenolone tablet could cause bad symptoms; the only supplements that are very safe to take orally are aspirin, cascara, some kinds of thyroid, small amounts of penicillin (30 mg), cyproheptadine (one-half to one milligram), and progesterone. Vitamin A and DHEA on the skin are safe, but you should put the vitamin A on your lower legs, and wash your hands so that none of it gets on your lips.” RP (2016)
07:34 - ‘People’s symptoms improve when they stop taking their supplements’
10:17 - Can supplements be problematic due to endotoxin?
14:07 - Are the manufacturing methods to blame for the irritation?
17:12 - Contamination, fillers, pill casings, etc.
18:09 - What is Ray’s process for determining if something is safe or not?
22:13 - ‘Unnamed and unidentified nutrients in natural foods’
23:40 - "We had an abundance of mangoes, papayas, and bananas here, but the pride of the islands, the most delicious fruit known to men, cherimoya, was not in season." —Mark Twayne (1866)
24:22 - ‘Marmalade is like a super drug’
25:02 - ‘A general rule about drugs’
27:05 - Finasteride as an example of an unsafe medical drug
29:11 - Ray’s experiences with nutrient deficiencies
36:42 - Ray’s thoughts on the versatility of the body
38:06 - The transgenerational impact on a person’s nutritional requirements
38:50 - “Meat eaters would normally get 1/4 to 1/2 grain of thyroid in their food every day if the whole animal were used.” RP
40:12 - Ways to minimize confusion when using thyroid or other substances
42:04 - Ray is working on getting his books online
42:31 - Nutritional requirements for a healthy vs. hypothyroid person
43:56 - Do healthy people need more vitamin A?
45:30 - Is there any definitive symptoms of vitamin A and K deficiency?
47:09 - Using the fat soluble vitamins topically
49:26 - Does Ray use the oily vitamins on his skin every day?
49:48 - Ray’s thoughts on B. subtilis and B. licheniformis (Biosporin)
51:57 - Ray expands on the relationship between aspirin and vitamin K
54:06 - Do people tend to be vitamin K deficient?
55:09 - Can well-cooked mushrooms replace the daily carrot?
56:30 - If Ray could take any substance on a desert island what would it be?
57:29 - What is Ray working on?
57:54 - “The newsletter is available by email now, and it’s $28 US which can be paid through PayPal, at raypeatsnewsletter@gmail.com.”

The Mysterious Conductor of the Hair Cycle Clock

The Mysterious Conductor of the Hair Cycle Clock

One of the oldest explanations for baldness in the Western world was the "exhaustion of nervous energy"—that is, the health and capability of the nervous system. In the 1881 book, American Nervousness, George W. Beard explains that baldness and many other problems increase at the expense of nervous energy due to the stress and strain of modern life.

Reversing Fibrosis in Male Pattern Baldness (Apigenin, Naringenin, Aspirin, and Gelatin)

Inflammation is an umbrella concept in pattern baldness that is given little attention in the mainstream. Polyunsaturated fats, mast cell migration and activation, prostaglandins, inflammatory cytokines, and the fibrotic environment these substances promote all appear to be involved in the progression of "the baldness field." Luckily, simple, safe, and available substances such as apigenin, naringenin, aspirin, and gelatin can help guard against the harmful effects of these inflammatory substances and in some cases help restore coherence to fibrotic tissues.

00:57 - Mitochondria, Oxidative Stress, and Fibrosis
03:03 - TGF-b1 and Fibrosis in The Bald Scalp
03:55 - Will a "Single Bullet" Approach Work?
04:49 - Fibrosis, Thyroid Function, Progesterone, and Helpful Foods
05:44 - Apigenin
06:44 - Naringenin
07:43 - Aspirin
08:57 - Gelatin


 

Generative Energy #30: What Keeps a Creative Person Going?

 
 

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01:09 - Danny’s thoughts on a purpose-driven life and meaningful work
02:22 - Should you wait until you’re better before being creative?
02:50 - “I was laying on the ground, maybe just four or five inches away and I was spreading the paint, mixing some different colours in. I was thinking to myself, ‘Man, what am I going to do now? Because this is one of the best, most fun things I’ve ever done.’” Taylor Phinney
04:59 - Creativity and the risk of being misunderstood
06:12 - Reinforcement of learned helplessness
07:12 - Danny’s many failings and mental anguish
08:33 - "People tend to hold overly favorable views of their abilities in many social and intellectual domains. The authors suggest that this overestimation occurs, in part, because people who are unskilled in these domains suffer a dual burden: Not only do these people reach erroneous conclusions and make unfortunate choices, but their incompetence robs them of the metacognitive ability to realize it. Across 4 studies, the authors found that participants scoring in the bottom quartile on tests of humor, grammar, and logic grossly overestimated their test performance and ability. Although their test scores put them in the 12th percentile, they estimated themselves to be in the 62nd. Several analyses linked this miscalibration to deficits in metacognitive skill, or the capacity to distinguish accuracy from error. Paradoxically, improving the skills of participants, and thus increasing their metacognitive competence, helped them recognize the limitations of their abilities." Unskilled and unaware of it: how difficulties in recognizing one's own incompetence lead to inflated self-assessments (1999)
13:58 - “If the path before you is clear, you're probably on someone else's.” Joseph Campbell
15:29 - Creating for yourself rather than others
17:41 - “It is the urge, which is evident in all organic and human life — to expand, extend, become autonomous, develop, mature — the tendency to express and activate all the capacities of the organism, to the extent that such activation enhances the organism or the self. This tendency may become deeply buried under layer after layer of encrusted psychological defenses; it maybe hidden behind elaborate facades which deny its existence; but it is my belief that it exists in every individual, and awaits only the proper conditions to be released and expressed.” Carl Rogers
18:38 - "The serial monogamies you mention are really important expressions of the rigidity that's the essence of the authoritarian culture. Just by putting them together you have illuminated them. In his later years Wilhelm Reich worried about how hard adults were to heal emotionally, but I think Freudianism just distracted him from what he probably knew as a communist, that people won't choose to change as long as there are no viable alternatives. " Ray Peat
20:25 - “You never change things by fighting the existing reality. To change something, build a new model that makes the existing model obsolete.” Buckminster Fuller
23:43 - “To avoid criticism say nothing, do nothing, be nothing.” Aristotle
24:43 - You don’t care what people think? Prove it!
28:13 - The journey of creativity would be cheap without risk
30:36 - "Everyday, I walk myself into a state of well-being and walk away from every illness. I have walked myself into my best thoughts, and I know of no thought so burdensome that one cannot walk away from it. But by sitting still, and the more one sits still, the closer one comes to feeling ill. Thus if one just keeps on walking, everything will be all right.” Kierkegaard
33:07 - "You never know what is enough unless you know what is more than enough." William Blake
33:59 - Danny’s experience with health authorities
34:43 - Celebrating “the expert”
36:36 - Choice and creativity
39:35 - Free speech as a creative act
40:04 - Why did Danny move to Mexico?

The Misunderstood Role of DHT in Male Pattern Baldness

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01:59 - Testosterone, 5-Alpha Reductase, and DHT in Normal Hair Growth
04:20 - The Relationship Between Serum Androgens and Baldness
06:17 - The Relationship Between 5-Alpha Reductase and Androgens in The Balding Scalp
12:53 - Summary

Generative Energy #29: How to Burn Fat on a Keto Diet (And Why You Shouldn’t)

 
 

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03:39 - Kyle Mamounis and Danny Roddy meet at AHS 2011
05:01 - Kyle’s origin story
06:41 - What is Kyle studying?
08:35 - Details on Kyle’s AHS 2016 talk
10:45 - Injecting CO2 and prostaglandins into ketosis
11:56 - Lactic acid in diabetes
13:24 - Glycolysis and mitochondrial respiration
14:30 - Is fat a superior fuel compared to glucose?
17:09 - The low carb fantasy view of metabolic stress
18:53 - Low carb people and “autoimmunity” issues
20:07 - Danny’s thoughts on “adrenal fatigue”
22:11 - What Kyle is researching
24:45 - Where do the genes fit in?
26:48 - The Randle effect as an “on” “off” switch for glucose metabolism
28:00 - Hepatic glycogen and the production of active thyroid hormone
30:20 - Turning down the generation of CO2 with ketosis
35:29 - Omega-3’s and mitochondrial respiration
38:18 - Thoughts on electrons and respiration
40:18 - Kyle’s future plans for AHS
43:08 - The “benefits” of ketosis — decreased endotoxin
47:24 - Products and objective science in nutrition
49:58 - How do you lose fat without entering ketosis?
51:26 - Danny was fatty on zero-carb
55:03 - Is it good to have a slow metabolism?
56:59 - Kyle’s final thoughts
57:45 - Kyle’s blog and where you can find him

Specialized Nutrition for Male Pattern Baldness

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Carbon Dioxide: The "Cure" for Male Pattern Baldness?

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Since producing 'Explaining The "Horseshoe" Shape of Male Pattern Baldness' I've been receiving a lot of questions about scalp massage and microneedling as potential therapies to increase blood flow and the delivery of oxygen and nutrients to balding hair follicles. While I don't think a relaxing massage would hurt, I'm extremely skeptical of microneedling as it seems to fall under the cut, burn, poison model of modern medicine. This video is an attempt at shifting the conversation away from methods that are as old as baldness itself, and towards a bioenergetic view of pattern hair loss with an emphasis on carbon dioxide.

The "Personality" of Male Pattern Baldness (Learned Helplessness)

“In many [pattern baldness patients], we encountered various types of ‘fixed smiles,’ and in a few, a rather striking, characteristic expression best described as a ‘toothy smile.’ Such rigid facial patterns are thought to reflect, psychologically speaking, defensive attitudes. Wilhelm Reich in his book, ‘Character Analysis,’ pointed out what he called ‘muscular armor’ as a frequently observed somatic reflection of ‘character armor.’ ‘Character armor’ refers to the psychologic defenses of a neurotic personality which serve as protection from feelings of insecurity and anxiety.”[1]

“Adaptive hormones can cause mental changes in man. Many patients who take ACTH or COL first develop a sense of extraordinary wellbeing and buoyancy, with excitement and insomnia; this is sometimes followed by a depression which may go so far as to create suicidal tendencies.”[2]

“Glucocorticoids exert early influences on the brain that tend to elevate mood and increase the sense of ‘well-being.’ Larger amounts can bring on temporary euphoria. However, the secondary effects include psychic depression. Patients with chronically elevated levels tend to have mood swings. They have been known to display bizarre behavior and to suffer hallucinations.”[3]

“Hyperprolactinemic patients were significantly more hostile, depressed, and anxious and had more feelings of inadequacy than family practice patients and non patient employees. The authors recommend measuring the serum prolactin levels of women with depression, hostility, anxiety, and symptoms or signs suggestive of hyperprolactinemia.”[4]

“Negative affectivity is a broad personality trait that refers to the stable tendency to experience negative emotions. Individuals who are high in negative affectivity are more likely to report negative affective mood states across time and regardless of the situation.”[5]

“High-negative affectivity individuals not only experience more feelings of dysphoria and tension, but have a negative view of self, report more somatic symptoms, and have an attention bias towards adverse stimuli. Overall, they seem to scan the world for signs of impending trouble…”[6]

“A common denominator among these studies documenting increased cortisol to laboratory challenges appears to be an increase in negative affectivity. The relationship between negative affectivity and cortisol activity has been well documented in several studies using structured laboratory stressors, such as public speaking and mental arithmetic and aversive stimulation as well as in the psychiatric literature relating to alterations in cortisol in depressed patients.”[7]

“Closely related to this openness to inner and outer experience in general is an openness to and an acceptance of other individuals. As a client moves toward being able to accept his own experience, he also moves toward the acceptance of the experience of others. He values and appreciates both his own experience and that of others for what it is. To quote Maslow again regarding his self-actualizing individuals: ‘One does not complain about water because it is wet, nor about rocks because they are hard… As the child looks out upon the world with wide, uncritical and innocent eyes, simply noting and observing what is the case, without either arguing the matter or demanding that it be otherwise, so does the self-actualizing person look upon human nature both in himself and in others.’ This acceptant attitude toward that which exists, I find developing in clients in therapy.”[8]  

“Making an effort to learn how to use techniques of food, hormones, light, activity, etc., is similar to the effort needed to work with a psychologist, and the effort itself is part of the therapy…”[9]

1. A theory of the pathogenesis of ordinary human baldness (1950)
2. The Story of Adaptation Syndrome (1952)
3. Endocrine Physiology (1985)
4. Hyperprolactinemia, distress, and hostility (1984)
5. Encyclopedia of Behavioral Medicine Negative Affectivity (2013)
6. Type D personality: A potential risk factor refined (2000)
7. Cortisol fluctuates with increases and decreases in negative affect (1999)
8. Carl Rogers on Abraham Maslow in the book, On Becoming a Person (1961)
9. Raymond Peat (2014)

Explaining The "Horseshoe" Shape of Male Pattern Baldness

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“The role of mast cells in male-pattern baldness is unknown, but the large numbers often present is a striking feature.”[1] 

"We postulate that because of the underlying anatomy, there is a relative microvascular insufficiency to regions of the scalp that lose hair in male pattern baldness and that is associated with local tissue hypoxia in those regions. The vascular supply of the scalp is derived from branches of the internal carotid artery and branches of the external carotid artery. The frontal region of the scalp, which loses hair in male pattern baldness, is supplied by the supraorbital and the supratrochlear arteries. These are relatively small branches of the internal carotid artery system. The temporal [sides] and occipital [back of head] regions of the scalp, which do not lose hair in male pattern baldness, are supplied by larger branches of the external carotid artery. Specifically, these are the superficial temporal, posterior auricular, and occipital arteries. Further, the frontal and vertex regions of the scalp overlie the galea aponeurotica, which is relatively avascular. The temporal and occipital regions of the scalp overlie the temporalis and occipitalis muscles, which provide a rich network of musculocutaneous perforator blood vessels. These anatomic differences contribute to the tenuous nature of the dermal blood supply to the frontal and crown regions of the scalp."[2]

"We hypothesized that this difference in pattern of prostaglandin D-synthase expression may constitute a developmental pattern inherent to normal as well as alopecic scalp skin, thus defining a ‘field’ vulnerable to acquired hair loss." “These data indicate that scalp is spatially programmed via mast cell prostaglandin D-synthase distribution in a manner reminiscent of the pattern seen in androgenetic alopecia.” "In a prior study of male pattern alopecia, increased numbers of mast cells have been seen in balding vertices compared to non-balding occipital scalp and, in fact, this pattern was also observed in five control subjects studied, though there were greater numbers of mast cells in the patients with alopecia.” "In the 1990’s mast cells were found to be actively degranulating in the inflammatory infiltrates of scalp with male pattern alopecia and this was proposed to contribute to perifollicular fibrosis.”[3] 

"Mast cells express the high-affinity estrogen receptor and studies have shown that estrogens augment their activities: in the presence of high levels of estrogens, mast cell responses to compound 48/80 are increased, leading to more substantial degranulation and release of histamine and serotonin.” "Progesterone is necessary for the maintenance of pregnancy and plays a key role in maintaining cervical integrity prior to labour induction. Progesterone can prevent the migration of mast cells in response to chemokines and down-regulate surface chemokine receptor expression. In addition, mast cell function can be altered by the presence of high concentrations of progesterone. For example, progesterone inhibits the secretion of histamine from mast cells. Notably, these observations would suggest that mast cells present within the uterus during pregnancy are quiescent and inhibited by high levels of progesterone, and also that recruitment of mast cell progenitors from the circulation may be limited.” "At present the prevalence of allergies, including allergic rhinitis, hayfever, eczema, food allergies and urticaria, is rising." [4]

"Results from this study provide the first evidence of a unique regulatory mechanism by which CO2 inhibits mast cell degranulation and histamine release by repressing stimulated increases in intracellular calcium. Thus, our data provide a plausible explanation for the reported therapeutic benefit of noninhaled intranasal delivery of 100% CO2 to treat allergic rhinitis." [5]

1. Male pattern alopecia a histopathologic and histochemical study (1975) 
2. Transcutaneous PO2 of the scalp in male pattern baldness: a new piece to the puzzle (1996)
3. A prostaglandin D-synthase-positive mast cell gradient characterizes scalp patterning (2014) 
4. The role of mast cells and their mediators in reproduction, pregnancy and labour (2010) 
5. Treatment of mast cells with carbon dioxide suppresses degranulation via a novel mechanism involving repression of increased intracellular calcium levels (2011)

Male Pattern Baldness: Hypothyroidism in Disguise?

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